• Detailed analysis of the dose dependence

  2024-06-06

  

  Detailed analysis of the dose dependence of Aβ effects revealed that at low amounts, Aβ can also act as a positive regulator of presynaptic activity, enhancing the neurotransmitter release probability and increasing the neuronal excitability [2]. The facilitator effects of low Aβ dose on excitatory

• Z-DQMD-FMK br Experimental procedures br Results br Discussi

  2024-06-06

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this Z-DQMD-FMK work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to than

• br cDNA cloning gene structure and chromosomal

  2024-06-06

  

  cDNA cloning, gene structure and chromosomal localization The cDNA for the leukocyte-type 12S-lipoxygenase was first cloned from porcine leukocytes [9], and later from mouse [10], [11], rat [12], [13], bovine [14] and rabbit [15] sources. The cDNA for the platelet-type 12S-lipoxygenase cDNA has b

• The specific mechanisms underlying glutamine dependency

  2024-06-06

  

  The specific mechanisms underlying glutamine dependency are still being explored, and current research indicates that the mechanisms likely vary between breast cancer subtypes. In HER2-positive breast cancer, increased levels of the transcriptional activator PGC-1α lead to expression of genes that m

• Modulating the ability of tumor cells to detoxify ROS is

  2024-06-06

  

  Modulating the ability of tumor pyrazine uses to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tumor cell

• br Conclusions br Introduction During

  2024-06-06

  

  Conclusions Introduction During numerous physiological processes, aldehydes are generated from a variety of endogenous and exogenous precursors including amino acids, carbohydrates, and lipids [1]. Most aldehydes are highly reactive and cytotoxic due to the strong electrophilic nature of the t

• br Disclosures br Author contributions br

  2024-06-06

  

  Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril

• Ozone induced innate inflammatory responses in

  2024-06-06

  

  Ozone-induced innate inflammatory responses in the lung involve neutrophil extravasation through enhanced trans-endothelial migration (Krishna et al., 1997). Catecholamines and glucocorticoids, which are increased by ozone inhalation (Bass et al., 2013, Miller et al., 2015, Miller et al., 2016a, Mil

• It is important to note that

  2024-06-06

  

  It is important to note that stable amnesia is, apparently, a general biological phenomenon and can be found in different animal species. In studies on rats, it was found that if reconsolidation of conditioned olfactory aversion memory was impaired by the antagonist of NMDA glutamate receptors, amne

• HT modulates cortical and hippocampal pyramidal cell functio

  2024-06-06

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal EIPA as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 2015, Da

• br Experimental section br Results and discussion br Conclus

  2024-06-06

  

  Experimental section Results and discussion Conclusions We present a simple, sensitive and selective assay of ADA activity and its inhibitor using the enzyme catalyzed reaction and the different interaction intensity of dye-labeled AD aptamer, aptamer/AD complex with GO. The as-proposed met

• Search sphere This sphere includes the acetylcholine binding

  2024-06-06

  

  Search sphere 1: This sphere includes the NKY 80 mg binding site between the α–γ subunits. The center point of the search area was located at x=35.26, y=77.67, z=137.74 and the initial search radius was set to 27Å which assures that the corresponding area outside the channel pore of the two subunit

• br Funding br Introduction l Dihydroxyphenylalanine l DOPA i

  2024-06-06

  

  Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side

• On the contrary evidence also

  2024-06-06

  

  On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer Adox require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend providing all the essen

• br Introduction The process of mitosis

  2024-06-05

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the 3MB-PP1 resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in regulating the

15659 records 88/1044 page Previous Next First page 上5页 8687888990 下5页 Last page