• Furthermore although ALKY are commonly recommended upfront i

  2020-07-27

  

  Furthermore, although ALKY are commonly recommended upfront in NET [2], [3], [4], oxaliplatin (Ox), either with 5-fluorouracile [29], [30], [31], [32], [33], [34], [35] or with gemcitabine [33], [36], has shown interesting activity with response rates ranging from 17% to 30%. In a retrospective stud

• DGK is not the only DGK isoform

  2020-07-27

  

  DGKε is not the only DGK isoform that has been associated with p53. It has been shown that DGKζ binds to p53 and modulates its activity in both the cytoplasm and the nucleus [39]. In the cytosol DGKζ promotes the degradation of p53 through the ubiquitin-proteosome system [39], also a likely mechanis

• In conclusion the magnitude of the association between prena

  2020-07-27

  

  In conclusion, the magnitude of the association between prenatal exposure to MeHg and child neuropsychological development appears to be modified by polymorphisms in CYP3A7 and CYP3A5 genes in some of the populations studied. These results provide some support for the hypothesis that CYP3A genes may

• br Results br Discussion Nuclear export

  2020-07-27

  

  Results Discussion Nuclear export of vRNP was originally thought to be mediated by the NEP/CRM1 interaction (O\'Neill et al., 1998), but several later studies indicated a role for NP in vRNP nuclear export: for example, LMB inhibits nuclear export of vRNP in a NEP-independent manner (Elton et

• Najafloo et al applied eSAFT

  2020-07-27

  

  Najafloo et al. [4] applied eSAFT-HR EoS to correlate the CO2 solubility in MDEA aqueous solutions in various conditions. In this work, 413 VLE data from different authors were utilized to model H2O + MDEA + CO2 system so that the overall overage absolute deviation (AAD) achieved was equal to 11.2.

• In addition the web application displays certain

  2020-07-27

  

  In addition, the web application displays certain information about the layers being viewed on the map at any given moment. This is done by the Legend component (left center), and as with the Map component, it acquires the necessary information from the LayerInfo component. Continuing examination of

• Ligand independent constitutively active variants have also

  2020-07-25

  

  Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases. In approximately 60% of patients harboring inflammatory hepatocellular adenomas (IHCAs), these adenomas have been caused by small in-frame deletions in the cytokine-binding domain o

• Dynasore br Methods br Results br Discussion On the other ha

  2020-07-25

  

  Methods Results Discussion On the other hand, surgical patients have to some extent stress during pre- and/or post-operative period. It is well known that CRF/CRF1 receptor is involved in the activation of HPA during acute and chronic stress (Papadimitriou and Priftis, 2009, Zelena et al.,

• To determine the time course of ZD P CPG DNA

  2020-07-25

  

  To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour Mometasone furoate were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggestin

• br Conclusion br Introduction The morphological variability

  2020-07-25

  

  Conclusion Introduction The morphological variability of aquatic plants is well documented, and in some cases has seriously constrained taxonomic resolution (Sculthorpe, 1967, Santamaría, 2002). Many of these variations are caused by the extensive phenotypic plasticity of aquatic plants, but t

• br Discussion Cytomegalovirus CMV is a herpes virus that cau

  2020-07-25

  

  Discussion Cytomegalovirus (CMV) is a herpes virus that causes primary infection in normal hosts and re-activation infection in compromised hosts with impaired CMI, e.g., organ transplants. Following primary infection, which may be severe, CMV becomes latent in lymphocytes. Reactivation may occur

• On the one hand levels

  2020-07-25

  

  On the one hand, levels of up to 20 nM P4 have been reported for a cyprinid species, Labeo rohita, in summer (Suresh et al., 2008). Similarly, P4 concentrations in tilapia, Oreochromis mossambicus, were found to range up to 27 nM (Cornish, 1998). Nevertheless in sturgeon P4 levels of approximately 3

• HQNO In addition to vasoconstrictor actions acute effects ET

  2020-07-25

  

  In addition to vasoconstrictor actions (acute effects), ET-1 exerts potent mitogenic actions on vascular smooth muscle cells and cardiac myocytes (chronic effects), hence causing vascular and cardiac hypertrophy [19,24,25]. These effects are mediated via stimulation of either ETA or ETB receptors, a

• RG7112 br Conflict of interest br

  2020-07-25

  

  Conflict of interest Acknowledgements We wish to thank Arantza Pérez (University of the Basque Country) for her technical contribution to this study. This work was supported by grants from the Jesús Gangoiti-Barrera Foundation, Gobierno Vasco (GIC07/84), MEC () and SAIOTEK (SA-2008/00046).

• br Expression and Tissue Functions of DDRs The DDRs

  2020-07-25

  

  Expression and Tissue Functions of DDRs The DDRs are widely expressed in different tissues, both during development and in adult organisms. DDR1 mRNA is found in many tissues in mice and humans, with high levels in brain, lung, kidney, spleen, and placenta (Di Marco et al., 1993, Johnson et al.,

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