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The cysteinyl leukotrienes cysLTs LTC LTD
2020-06-05
The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the e
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The cysteinyl leukotrienes cysLTs LTC LTD
2020-06-05
The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the ef
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Atipamezole hydrochloride Fig S an
2020-06-05
Atipamezole hydrochloride (Fig. S1), an α2-adrenoceptor antagonist, is commonly used by veterinarians to recover animals from sedation-anesthesia induced by α2-adrenoceptor agonists. Recent studies in animals suggest that atipamezole might have beneficial effects in LCQ-908 damage repair, it also h
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3,4-DAA The crystal structure of LiCoO is
2020-06-05
The crystal structure of LiCoO2 is presented in Fig. 1. We can notice that the Li and Co atoms occupy the centers of two different edge-sharing [CoO6]-octahedra, which results in formation of separate Li and Co layers. Hence, the layered structure of LiMO2 is able to intercalate lithium into transit
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The performance of the qCPA
2020-06-05
The performance of the qCPA approaches is similar with regards to the derivative properties of CO2 and for mixtures of CO2+self-associating compounds. For CO2+n-alkanes the four-parameter versions of qCPA both perform somewhat better than the three-parameter version. Nevertheless this modest improve
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As the communications interface was
2020-06-05
As the communications interface was developed by two separate organisations with differing software processes and tools, a modular approach to the safety case was deemed appropriate. The modular approach related the communications interface safety argument to the safety arguments for both the ACS an
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Epitope analyses of AT AA
2020-06-04
Epitope analyses of AT1-AA and ET-AA indicate that the Mouse Angiopoietin-2 / ANG2 / ANGPT2 Protein (His Tag) of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort
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Preliminary studies suggest that dimerization
2020-06-04
Preliminary studies suggest that dimerization of the AT1 receptor occurred during the biosynthesis in the endoplasmic reticulum before surface expression [27,40], which may explain the presenece of these myelin basic protein before the addition of any ligand. Our results showed that the presence o
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br Chemistry A total of new ThDP
2020-06-04
Chemistry A total of 35 new ThDP analogs in the series of 7, 12, 15, and 19 were designed and synthesized (Scheme 1). The synthetic route is simple and convenient. In this synthetic route, 4-amino-2-methylpyrimidine-5-carbaldehyde 3 is a key intermediate for the synthesis of title compounds 7, 1
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We also observed reduced insulinotropic
2020-06-04
We also observed reduced insulinotropic effects after intravenous administration of both GLP-1 and GIP with atropine, whereas no inhibition was observed by atropine of the direct effects of GLP-1 and GIP action on beta-cells in the islet experiments. This suggests that the reduction in circulating i
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br Conflicts of interest br Introduction Diacylglycerols
2020-06-04
Conflicts of interest Introduction Diacylglycerols (DAGs) and phosphatidic (+)-Apogossypol (PA) play fundamental roles in biology as basic components of membranes, intermediates in lipid metabolism, and secondary messengers in cellular signaling (Carrasco and Merida, 2007, Fang et al., 2001).
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br Molecular modeling study Molecular modeling study was
2020-06-04
Molecular modeling study Molecular modeling study was essentially needed to understand and interpret the DHFR inhibitory pattern of this new class of compounds. Computational docking is an algorithm designed to estimate two main terms. The first is to determine the suitable position and the orien
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Although several examples of selective reduction
2020-06-04
Although several examples of selective ampar of α-diazoesters to α-hydrazonoesters have been described in the literature, reports on practical and general examples of such a process are scarce. In this context, there was a need to devise a mild and general method for the selective reduction of α-di
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Xenobiotic metabolism primarily occurs in
2020-06-04
Xenobiotic metabolism primarily occurs in liver, which contains many enzymes to catalyze the transformation of xenobiotic. Usually, cytochrome P-450s (CYP450s) act as the first response for biotransformation of xenobiotic in organisms. CYP450s generally consist of various subfamily enzymes which can
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In agreement with the study on porcine microsomes Ekstrand
2020-06-04
In agreement with the study on porcine microsomes (Ekstrand et al., 2015), our results indicated a somewhat higher degree of inhibition of CYP2E1 activity in the male pools compared to females. Nevertheless, the degree of this Istaroxime hydrochloride synthesis inhibition did not reach 50%, indicat
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