• br Conclusion Interactions between neurons and astrocytes de

  2021-10-07

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• In this study we demonstrated that while Cu

  2021-10-07

  

  In this study, we demonstrated that while Cu(I) does not affect LPS induced iNOS XL228 synthesis it inhibits NO release from microglia. Cu(I)-induced GSNOR inhibition and GSNO depletion is more in line with alternative (non-inflammatory) polarization. These results extend our previous findings that

• br Discovery of GPR A

  2021-10-07

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• br ACKNOWLEDGMENTS br Introduction Odorant receptors ORs

  2021-10-04

  

  ACKNOWLEDGMENTS Introduction Odorant receptors (ORs) are the largest subfamily of G protein-coupled receptors (GPCRs) and are mainly expressed by olfactory sensory neurons in the nose for the detection of various odorants [1]. However, more recent reports suggest that ORs are also expressed an

• ACY-241 br Materials and methods br Results and

  2021-10-04

  

  Materials and methods Results and discussion Conclusions Acknowledgments The authors are grateful to Dr. N. Prevete for providing the human AGS shCTR and AGS shFPR2 cells. This work was supported by POR Campania FSE 2007-2013 Project CREME and Ministry of Health, Italy, RF-2011-02349269.

• Pyrrolidinedithiocarbamate ammonium Our previous study had s

  2021-10-04

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β Pyrrolidinedithiocarbamate ammonium [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may

• br Characterization of quantal exocytosis by amperometry A s

  2021-10-03

  

  Characterization of quantal exocytosis by amperometry A secretory vesicle experiences four phases during exocytosis: (i) cargo packaging & translocation, (ii) vesicle docking & priming; (iii) fusion pore formation; (iv) fusion pore expansion and cargo secretion (Fig. 1a). The release of monoamine

• br Statistical analysis The mean standard deviation median

  2021-10-03

  

  Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t

• br Introduction Local anesthetics LAs are a set of common

  2021-10-03

  

  Introduction Local anesthetics (LAs) are a set of common medicines used for pain management in clinical settings. Up to now, LAs have been extensively used for peripheral nerve blocks, interventional spinal procedures, and epidural anesthesia [1]. In addition to their anesthetic and analgesic eff

• br Materials and methods br Results br Discussion Genetic

  2021-10-03

  

  Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data

• br Methods br Results br Discussion Peptide therapeutics

  2021-10-03

  

  Methods Results Discussion Peptide therapeutics represents a unique class of biopharmaceuticals that continues to evolve in drug discovery and development. We and others have been particularly interested in bioengineering innovative pGC-A and/or pGC-B peptide activators. This has been succe

• Compound was synthesized in a racemic fashion with this

  2021-10-02

  

  Compound was synthesized in a racemic fashion with this study and plans for an enantioselective synthesis could be developed based on the activity of racemic . Synthesis of compound followed a slightly different synthetic route due to the ineffectuality of the S2 reaction on the secondary position

• The previous study demonstrated that

  2021-10-02

  

  The previous study demonstrated that the main CYP isoforms present in the human mmp endocrinology included CYP46A1, 2J2, 2U1, 1B1, 2E1 and 2D6 (Dutheil et al., 2009b, 2010). CYP1B1 and CYP2U1 were found in the mitochondrial and microsomal fractions of astrocytes in the human frontal lobe, hippocamp

• Recent studies revealed that synthetic

  2021-10-02

  

  Recent studies revealed that synthetic oligomeric Aβ1-42 decreased GLT-1 expression and promoted mislocalization of GLT-1 from the cell surface of primary astrocytes, leading to glutamate dyshomeostasis in synapses (Abdul et al., 2009, Scimemi et al., 2013). To address the cause for reduction of ast

• uPAR promotes cell associated proteolysis

  2021-10-01

  

  uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot

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