• Histamine which was used as the

  2022-03-17

  

  Histamine, which was used as the agonist, had low potencies in our functional experiments when compared to its affinity from binding studies (e.g. Lim et al., 2005). This phenomenon is related to the fact that the coupling of the presynaptic receptor to the transduction machinery and the final funct

• It is an exciting time for translational histamine research

  2022-03-17

  

  It is an exciting time for translational histamine research, since preclinical studies show potential value for histamine receptor ligands. As reviewed above, there are several concerns for future studies of histamine and its role in the CNS. 1) Because of the availability of HDC-Cre mice (Williams

• Histamine H and H receptors

  2022-03-17

  

  Histamine H1 and H2 receptors are considered as low affinity receptors (pKi of 4.2 and 4.3 respectively), whereas histamine H3 and H4 receptors as a high affinity receptors (pKi of 8 and 8.2 respectively) (Schreeb et al., 2013). Therefore it might well be that other histamine receptors might be invo

• The endocannabinoid system ECS consists of cannabinoid CB an

  2022-03-16

  

  The endocannabinoid system (ECS) consists of cannabinoid (CB)1 and CB2 receptors, their endogenous ligands anandamide and 2-arachidonylglycerol, and the synthesizing and degrading enzymes for these ligands. Cannabinoids and the ECS are involved in the regulation of GI motility in physiological and p

• The aim of our study was

  2022-03-16

  

  The aim of our study was to investigate the polymorphisms of RAGE and glyoxalase I gene and sRAGE serum levels in patients with pathological pregnancy trying to describe the genetic background of pathological pregnancy or to find a new biochemical marker (sRAGE) of these pathological states in pregn

• Trypanosomatid GLO enzymes are monomeric and contain a

  2022-03-16

  

  Trypanosomatid GLO2 enzymes are monomeric and contain a zinc–iron binuclear metal center (Irsch and Krauth-Siegel, 2004, Silva et al., 2008), similar to all other glyoxalases II. As mentioned, in T. brucei there are two GLO2 genes but only one encodes an enzyme with glyoxalase II activity (Irsch and

• br Funding This work was supported by grants of

  2022-03-16

  

  Funding This work was supported by grants of the National Academy of Sciences of Ukraine within the programs “Molecular and cellular biotechnologies for medicine, industry and agriculture” (#35-2018), “Scientific Space Research for 2018-2022” (#19-2018), “Smart sensory devices of a new generation

• br Spatial working memory is GluR A dependent The radial

  2022-03-16

  

  Spatial working memory is GluR-A-dependent The radial maze task also allowed us to study hippocampus-dependent spatial working memory. On spatial working memory tasks, the correct spatial response that the animal must make varies from trial to trial and is dependent on some conditional, trial-spe

• The rapid actions of glucocorticoids range from

  2022-03-16

  

  The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune Octreotide acetate [12], [13], [14]. Many different kinase signaling pathways have been implicated in the rapid

• br STAR Methods br Acknowledgments We would like

  2022-03-16

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• In the second part of this

  2022-03-16

  

  In the second part of this study, we investigated the influence of GH on the aldehyde dehydrogenase of the ghrelin receptor, GHSR-1a, at the mRNA and peptide levels in cultured whole follicles. Regulation of the expression of GHSR-1a has a key role in the actions of ghrelin in target tissues. Using

• br Conflict of interest statement br Introduction br

  2022-03-16

  

  Conflict of interest statement Introduction Gap junction assembly Induced disassembly of gap junctions The regulation of connexin and gap junction turnover are still not well understood. This is, in part, due to the fact that while the overall turnover of connexin molecules is fairly con

• Studies regarding secretase nowadays aim at elucidating how

  2022-03-16

  

  Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran

• Recent evidence indicates that prolonged vasoconstriction

  2022-03-16

  

  Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs TH588 polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleation and elongati

• br PEPCK This enzyme decarboxylates and then

  2022-03-15

  

  PEPCK This enzyme decarboxylates and then phosphorylates oxaloacetate to form phosphoenolpyruvate (PEP) in the second step of gluconeogenesis after the carboxylation of pyruvate catalyzed by PC. PEPCK1 (PEPCK-C, encoded by the PCK1 gene) and PEPCK2 (PEPCK-M, encoded by the PCK2 gene) are two isof

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