• Colorectal cancer CRC is the

  2022-04-02

  

  Colorectal cancer (CRC) is the leading cause of cancer deaths in Taiwan and is also a most common cancer in the world (Huang et al., 2012, Jemal et al., 2011). With early detection and treatment in the initial stage, CRC can be recognized as curable in comparison with other malignant tumors (Levin e

• Remarkably most of these molecules are also quite effective

  2022-04-02

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, com

• Nonetheless several questions remain to be answered about FA

  2022-04-02

  

  Nonetheless, several questions remain to be answered about FAAH inhibition to address cannabis use disorder. The trial was of short duration (4 weeks), whereas most clinical trials in this field have been for 8–12 weeks., , , Although motivational deficits are commonly present in cannabis users and

• The more important effect of

  2022-04-02

  

  The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced Nemonapride release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic teenagers

• br References and recommended reading Papers of particular i

  2022-04-02

  

  References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Male sexual maturation includes gonadal maturation, secondary sexual characteristics, and the attainment of reproductive capacity [1]. Male sexual di

• Methscopolamine br Materials and methods br Results br

  2022-04-02

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• In first wave first generation drugs telaprevir and boceprev

  2022-04-02

  

  In 2013, first-wave, first-generation drugs telaprevir and boceprevir was the first protease inhibitors (PIs) incorporated in Brazilian Clinical Guidelines for the treatment of patients infected with HCV melanocortin receptor 1. Based on this 2013 Clinical Guideline, telaprevir could be used for bo

• br Author Contributions br Acknowledgments

  2022-04-02

  

  Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members

• The GPR receptor is also emerging as an

  2022-04-02

  

  The GPR55 receptor is also emerging as an important therapeutic target. GPR55−/− mice possess no overt phenotype, but were protected in models of inflammatory and neuropathic pain (Staton et al., 2008). Staton et al. (2008) reported that no GPR55 mRNA could be detected by RT-PCR in the animals. Also

• br Activity dependent control of

  2022-04-02

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed Cy5.5 maleimide (non-sulfonated) mg in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating den

• As disclosed in our preceding paper medicinal

  2022-04-02

  

  As disclosed in our preceding paper, medicinal chemistry SAR optimization of an HTS hit led to the discovery of , a potent and selective GPR119 agonist. This scaffold differs significantly from the ‘classical’ GPR119 pharmacophore, exemplified by the examples and (). Notably, Panobinostat lacks

• There is sufficient evidence to indicate that kisspeptin pla

  2022-04-02

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH Splitomicin and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was cl

• Na K ATPase adenosine triphosphate ATP and astrocytic

  2022-04-01

  

  Na+/K+-ATPase, Benidipine HCl receptor and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be increase

• Although in in vitro analyses

  2022-04-01

  

  Although in in vitro analyses GANT61 sensitized Daoy Dimesna to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-group vari

• The fine interplay among post translational

  2022-04-01

  

  The fine interplay among post-translational modifications and intersection with other pathways, such as PI3K–AKT, has a crucial role in the regulation of GLI activity and in the generation of their repressor forms 40, 41, 42. In addition to β-TrCP, for example, other E3 ligases belonging to the real

16338 records 473/1090 page Previous Next First page 上5页 471472473474475 下5页 Last page