• Apelin APJ triggers a variety of

  2023-09-21

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 s

• In conclusion our study has identified a spl

  2023-09-21

  

  In conclusion, our study has identified a splice site teniposide (c.1769-1G > C) in the AR gene from two patients with complete androgen insensitivity syndrome. The c.1769-1G > C mutation may provide us new insights into the molecular mechanism involved in splicing defects underlying CAIS. Our find

• In our sequential model for

  2023-09-21

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Minocycline HCl in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in th

• The complex role of the

  2023-09-20

  

  The complex role of the human intestinal microbiota is emerging and its functions has been elucidated when considering energy metabolism, nutrient digestion, vitamin synthesis, epithelial defenses and immune responses [34]. The colon is responsible for salvage of energy and possibly nitrogen from ca

• br Impact of global AHR deficiency on diet induced

  2023-09-20

  

  Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s

• induced pluripotent stem cell In the search for more specifi

  2023-09-20

  

  In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste

• br The role of AMPK beyond energy

  2023-09-20

  

  The role of AMPK beyond AMD3100 homeostasis: regulating metabolism AMPK plays a major role in glucose homeostasis by modulating glucose transport in peripheral tissues [20]. Skeletal muscle, one of the main peripheral tissues involved in glucose uptake and disposal, expresses glucose transporter

• Our published data showed that

  2023-09-20

  

  Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function

• br Acknowledgments br Introduction Hypospadias is a common c

  2023-09-20

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• br Cytochrome b br Cytochrome P hydroxylase

  2023-09-20

  

  Cytochrome b5 Cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1) A number of P450s involved in steroid biosynthesis are multifunctional as they carry out two or more sequential hydroxylation reactions on the same substrate(s). P450 17A1 is a dual function endoplasmic reticulum enzyme enco

• These experiments make it clear that one can study the

  2023-09-20

  

  These experiments make it clear that one can study the effect of antimalaria drugs that target the DHFR enzyme of P. falciparum by transferring the malaria enzyme into S. cerevisiae. The ease of growth and manipulation of the yeast make it easy to measure the sensitivity of any particular dhfr allel

• AR is expressed in cell specific human ovarian follicles at

  2023-09-19

  

  AR is expressed in cell-specific human ovarian follicles at all stages of follicular development [25]. Administration of androgens in animals demonstrated initiation of follicular recruitment, stimulation of early stages of follicular growth, and increase in the number of growing follicles [26,27].

• br Androgen interference with the action of arachidonic acid

  2023-09-19

  

  Androgen interference with the action of arachidonic M871 metabolites’ actions; the other side of the coin Arachidonic acid, being a polyunsaturated fatty acid present in the phospholipids of the membrane of cells, is highly abundant within the organism. It is mainly involved in cellular signali

• Testosterone can be converted into estrogens by

  2023-09-19

  

  Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli

• Various compounds have been designed to

  2023-09-19

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic mk 801 moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a potent

16350 records 267/1090 page Previous Next First page 上5页 266267268269270 下5页 Last page