• In a missense mutation at codon

  2023-12-26

  

  In 1989, a missense mutation at codon 102 of the PRNP gene was first reported to be associated with GSS and, in 1991, the same mutation was also found in affected members of the “H” family (Hsiao et al., 1989; Kretzschmar et al., 1991). By 1995, the pedigree of the “H” family included 221 family mem

• Estradiol br Eprosartan The AT R

  2023-12-26

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Estradiol and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events, indep

• br Role of AR in models

  2023-12-26

  

  Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig

• br Acknowledgments and Disclosures br Alzheimer s disease as

  2023-12-26

  

  Acknowledgments and Disclosures Alzheimer's disease as a synaptic pathology Alzheimer's disease (AD) is a chronic neurodegenerative 67 7 disorder and the most common cause of dementia in the elderly. Progressive depositions of amyloid plaques and neurofibrillary tangles together with degenerat

• br Perspective AA LA and other PUFAs

  2023-12-26

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• KU14R This evidence suggests the strong clinical relevance

  2023-12-25

  

  This evidence suggests the strong clinical relevance of the identification of acquired resistance mechanisms for a proper therapeutic decision in patients with ALK-rearranged NSCLC. When the tissue is not available, the analysis of circulating tumor DNA (cfDNA) can be a valid alternative for the det

• Cancer stem cells CSCs may

  2023-12-25

  

  Cancer stem cells (CSCs) may have been first identified in teratocarcinomas [11], [12], with its initial clues date back to the 19th century [13]. Kleinsmith and Pierce [12] established the immortal pluripotent teratocarcinoma lines from a single transplanted multi-potent malignant cell, strongly su

• br Parkinson s Disease and the immune system Parkinson

  2023-12-25

  

  Parkinson’s Disease and the immune system Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s, which affects 10 million people globally and is characterized by rigidity, bradykinesia, tremors, and gait instability (O’sullivan et al., 2007). The patholo

• To examine whether the interaction between

  2023-12-25

  

  To examine whether the interaction between mGlu7 and α1-adrenergic receptors could be confirmed at a behavioural level, we performed the FST in mice. This test has value in predicting the antidepressant-like effect of drugs or environmental manipulations (Krishnan and Nestler, 2008, Krishnan and Nes

• In conclusion the results of this investigation suggest that

  2023-12-25

  

  In conclusion, the results of this investigation suggest that the involvement of PGE2 in the pathogenesis of pulpal inflammation and repair may be related to its induction of cAMP production. PGE2-induced cAMP production in dental pulp cells is mediated by binding to the EP2 receptor, activation of

• br Materials and methods br Results br Discussions Diabetes

  2023-12-25

  

  Materials and methods Results Discussions Diabetes is mainly divided into Type 1 diabetes and Type 2 diabetes [16]. Type 2 diabetes, featured by insulin resistance, results from environmental factors and poor eating habits [2]. Type 2 diabetes accounts for more than 95% of the diabetic pati

• Since the introduction of zebrafish

  2023-12-25

  

  Since the introduction of zebrafish into the laboratory, many milestones have been achieved that firmly establish this organism as a prominent genetic model for biology and medicine. Many features make this species an organism of easy maintenance in laboratory which provides advantages to understand

• Introduction Mammalian cells express the seven STAT family m

  2023-12-25

  

  Introduction Mammalian pgc-1α inhibitor express the seven STAT family members STAT1, −2, −3, −4, −5A, −5B, and −6 [1], [2]. All STATs exert physiologically important roles as homo- and heterodimers [2], [3], [4]. Cytokines and growth factors activate STATs through the activation of kinases that pho

• A promising target that is involved in

  2023-12-25

  

  A promising target that is involved in the biosynthesis of the precursor LTA4 is the 5-LO-activating protein (FLAP), which in vivo is seemingly indispensable for LT formation [8], [9]. FLAP, a member of the MAPEG family (membrane-associated proteins in eicosanoid and glutathione metabolism), is an i

• Forskolin br Materials and methods br Results br Discussions

  2023-12-25

  

  Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se

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