• Es en este sentido que el desarrollo econ

  2018-11-09

  

  Es en este sentido que el desarrollo económico en su verdadero significado resulta ser hoy como meta sólo una suerte de espejismo, aunque ideológicamente continúe operando como un mito, según lo señalara muy acertadamente años atrás el destacado economista brasileño Celso Furtado (1975). En este con

• br March y Levinthal describen que una empresa busca en

  2018-11-09

  

  March (1991) y Levinthal (1998) describen que una empresa busca en principio la novedad para hacerse de uno o varios nichos y luego explotar los que resulten más beneficiosos. El proceso iniciaría de exploración de diseños (en productos, rutinas y organizaciones) al cual le continúa uno de explota

• Sea cual fuere la explicaci n de las

  2018-11-09

  

  Sea cual fuere la explicación de las causas del estancamiento económico, lo que es un hecho obvio es que ha llevado purinergic receptor la caída del Producto Interno Bruto (pib). Según cifras oficiales en el periodo 1982-2010 el pib sólo creció en promedio anual un 2.2%, mientras que en 1933-1981 fu

• Para estimar la distribuci n de riqueza para los pa

  2018-11-09

  

  2) Para estimar la distribución de riqueza para los países sin datos, los autores hicieron uso de los datos de distribución del ingreso de 145 países registrados en el conjunto de datos wiid −otra vez, amable lector, se mezclaron dos variables por definición esencialmente distintas, el ingreso, un f

• Disclosure br Integration of biomarkers into the majority

  2018-11-09

  

  Disclosure Integration of biomarkers into the majority of drug development programs has led to a need for robust measurements and assay validation techniques for analyses of biological samples. The importance of solid methodologies for biomarker assessment is heightened by the fact that new drugs

• An important limitation of prior biomarkers studies

  2018-11-09

  

  An important limitation of prior biomarkers studies is that they included all stages of RCC (Takahashi et al., 2001; Sultmann et al., 2005; Kosari et al., 2005; Jones et al., 2005; Zhao et al., 2006; Cancer Genome Atlas Research N, 2013; Brannon et al., 2010), limiting their applicability to patient

• br Materials and methods br Results br Discussion

  2018-11-08

  

  Materials and methods Results Discussion Free radical damage can be considered as one of the major causative factors involved in many diseases such as inflammation and dementia. It is well established that anti-oxidants are capable of preventing injury to blood vessel membranes, thereby opt

• MRG was initially isolated as a member of gene family

  2018-11-08

  

  MRG15 was initially isolated as a member of gene family that is related to cellular senescence and cell growth control and is evolutionarily highly conserved (). MRG15 has a chromodomain in the N-terminus () and can directly bind to di- or tri-methylated histone H3 at lysine 36 (H3K36me) through thi

• Subsets of undifferentiated human ES cells have been propose

  2018-11-08

  

  Subsets of undifferentiated human ES cells have been proposed based upon studies of surface antigen markers, such as SSEA3 (Enver et al., 2005) or CD9 and GCTM2 (Laslett et al., 2007). SSEA3 is a cell surface antigen that is rapidly down-regulated as human ES cells differentiate (Draper et al., 200

• br Results br Discussion We have demonstrated that

  2018-11-08

  

  Results Discussion We have demonstrated that the hPSC-derived HBCs could be maintained on a human LN111-coated dish in an integrin α6- and β1-dependent manner (Figure 1). It is known that undifferentiated hPSCs could be maintained on a human LN511-coated dish but not on a human LN111-coated di

• While the in vivo significance of

  2018-11-08

  

  While the in vivo significance of our in vitro findings was examined in xenograft and metastasis studies, we observed a dramatic suppression of tumor growth and metastasis of SW480 CRC hsp90 inhibitors by EDA silencing, which is associated with increased apoptosis and reduced expression of a cell p

• br Materials and methods br Results br Discussion We

  2018-11-08

  

  Materials and methods Results Discussion We have demonstrated the efficient generation of high numbers of bfCNs from hPSCs via an expandable basal forebrain NSC intermediate. This is of particular interest as bfCNs are one of the primary populations affected in AD, and our protocol provides

• br The important role of the Hippo

  2018-11-08

  

  The important role of the Hippo kinase cascade in suppressing cell proliferation led Heallen, Martin, and colleagues to hypothesize that Hippo signaling deficiency would cause cardiac overgrowth. This hypothesis was supported by the cardiac-restricted inactivation of Mst1/2, Sav1, and Lats2, which

• synthase In demyelinating diseases injury of myelin

  2018-11-08

  

  In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as

• Our experiments suggest that Runx may be a useful

  2018-11-08

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic ras pathway injury. Runx1 over-expression has been demonstrated to facilitate neuronal differentiation and long-range

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