• br Contributors br Declaration of Interests br Acknowledgmen

  2018-10-23

  

  Contributors Declaration of Interests Acknowledgments This investigation received financial support from the Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, PAE-PID-00127, PAE-PICT-207-02332 and PICT-0240 to VEG); University of Buenos Aires (20020100100221 and 20020130100236

• An association between reconstitution of

  2018-10-23

  

  An association between reconstitution of CD4 T-cells and impaired lung function, measured as oxygen saturation, has been shown in a murine model for IRIS using Mycobacterium avium (). However, our study investigated the association between paradoxical TB-IRIS, change in MMPs on ART, and pulmonary fu

• br Acknowledgements Conflict of Interest br Financial Suppor

  2018-10-23

  

  Acknowledgements Conflict of Interest Financial Support The work was financially supported by a grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health (grant number R21AA023521-01A1 to MR). The sponsor of the study (NIAAA) had no role in

• We sought to further investigate

  2018-10-23

  

  We sought to further investigate the phenomenon of amoxicillin/clavulanate susceptibility using comparative genomics. A phylogenetic analysis indicated that a large proportion of MDR and XDR isolates in our dataset were part of a LAM4 clade, which was responsible for the famed Tugela Ferry XDR outbr

• To prevent the negative impact

  2018-10-23

  

  To prevent the negative impact of hemolysis, the U.S. Food and Drug Administration set the upper threshold of hemolysis in a RBC unit to be transfused at 1% but some RBC units stored under standard blood banking conditions fail to meet this requirement due to factors that may be donor specific (Mish

• Conversely ECM accumulation in the liver is a

  2018-10-23

  

  Conversely, ECM accumulation in the liver is a hallmark of hepatic fibrosis and is associated with hepatic stellate cell activation due to inflammatory signaling (Bataller and Brenner, 2005). ECM reprogramming is necessary for adipose growth and expansion on energy dense diets, and fibrosis in fat t

• The results of the hierarchical

  2018-10-23

  

  The results of the hierarchical regression suggest that countries with higher mean years of schooling are less likely to report positive vaccine sentiment, however within a country those with some education hold more positive views on vaccine importance, effectiveness, and religious compatibility (t

• The in vivo replication kinetics of

  2018-10-23

  

  The in vivo replication kinetics of ZIKV in natural human infections remains elusive. The neurotropic nature of ZIKV has been evidenced by mouse experiments (Cugola et al., 2016) and clinical investigations (Carteaux et al., 2016). Our necropsy data from two animals demonstrate that the contemporary

• Although de novo hepatic lipogenesis contribute to liver FFA

  2018-10-23

  

  Although de novo hepatic lipogenesis contribute to liver FFA abundance, circulating FFA represent greater pools for hepatic FFA accumulation. Under physiologic conditions, intrahepatic FFA can be re-esterified and stored as TG in lipid droplets (Neuschwander-Tetri, 2010). Recent studies demonstrated

• br Funding Sources Support for this project was provided

  2018-10-23

  

  Funding Sources Support for this project was provided to A.J.M. through grants from Susan G. Komen for the Cure,KG110601 and the Pennsylvania Department of Health, SAP #4100068718. G.C.P. and A.J.M. also receive financial support from NIH grants CA159337 and CA159315. No funding sources including

• Approximately of nephroblastomas are related to germline

  2018-10-23

  

  Approximately, 10%–15% of nephroblastomas are related to germline pathogenic variants or epigenetic alterations formed in the early stage of embryogenesis (Dome and Huff, 1993). Roughly 1%–2% of cases have at least one relative also developed Wilms\' tumor. Germline genetic and epigenetic variations

• Taken together these findings provide strong evidence for a

  2018-10-23

  

  Taken together, these findings provide strong evidence for a unique subset of HNSCC patients defined by DNA methylation profiles. Further research is required to determine the connection between CIMP and mutations, however, the correlations between individual CIMPs and specific somatic gene mutatio

• In the present study we

  2018-10-23

  

  In the present study, we have put considerable effort on carefully searching for published studies, setting strict criteria for study inclusion. There are some advantages that should be illustrated. Firstly, we have conducted a comprehensive search to identify more eligible studies thus, makes our a

• Planarians are a particularly well suited

  2018-10-23

  

  Planarians are a particularly well-suited animal model for the study of neoblast function, given the remarkable enrichment of this cell type in these animals (Reddien, 2013). Here, we showed that phagocyte depletion had no impact on instructed immunity. Instead, we found evidence of a critical role

• br Translating Senolytics into Clinical Treatments

  2018-10-23

  

  Translating Senolytics into Clinical Treatments Healthspan, lifespan, or other very long-term potential endpoints for clinical trials of interventions that target basic aging processes, including SASP-inhibitors or senolytics, would be difficult or next to impossible to study for reasons that are

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