• To prevent the negative impact

  2018-10-23

  

  To prevent the negative impact of hemolysis, the U.S. Food and Drug Administration set the upper threshold of hemolysis in a RBC unit to be transfused at 1% but some RBC units stored under standard blood banking conditions fail to meet this requirement due to factors that may be donor specific (Mish

• Conversely ECM accumulation in the liver is a

  2018-10-23

  

  Conversely, ECM accumulation in the liver is a hallmark of hepatic fibrosis and is associated with hepatic stellate cell activation due to inflammatory signaling (Bataller and Brenner, 2005). ECM reprogramming is necessary for adipose growth and expansion on energy dense diets, and fibrosis in fat t

• The results of the hierarchical

  2018-10-23

  

  The results of the hierarchical regression suggest that countries with higher mean years of schooling are less likely to report positive vaccine sentiment, however within a country those with some education hold more positive views on vaccine importance, effectiveness, and religious compatibility (t

• The in vivo replication kinetics of

  2018-10-23

  

  The in vivo replication kinetics of ZIKV in natural human infections remains elusive. The neurotropic nature of ZIKV has been evidenced by mouse experiments (Cugola et al., 2016) and clinical investigations (Carteaux et al., 2016). Our necropsy data from two animals demonstrate that the contemporary

• Although de novo hepatic lipogenesis contribute to liver FFA

  2018-10-23

  

  Although de novo hepatic lipogenesis contribute to liver FFA abundance, circulating FFA represent greater pools for hepatic FFA accumulation. Under physiologic conditions, intrahepatic FFA can be re-esterified and stored as TG in lipid droplets (Neuschwander-Tetri, 2010). Recent studies demonstrated

• br Funding Sources Support for this project was provided

  2018-10-23

  

  Funding Sources Support for this project was provided to A.J.M. through grants from Susan G. Komen for the Cure,KG110601 and the Pennsylvania Department of Health, SAP #4100068718. G.C.P. and A.J.M. also receive financial support from NIH grants CA159337 and CA159315. No funding sources including

• Approximately of nephroblastomas are related to germline

  2018-10-23

  

  Approximately, 10%–15% of nephroblastomas are related to germline pathogenic variants or epigenetic alterations formed in the early stage of embryogenesis (Dome and Huff, 1993). Roughly 1%–2% of cases have at least one relative also developed Wilms\' tumor. Germline genetic and epigenetic variations

• Taken together these findings provide strong evidence for a

  2018-10-23

  

  Taken together, these findings provide strong evidence for a unique subset of HNSCC patients defined by DNA methylation profiles. Further research is required to determine the connection between CIMP and mutations, however, the correlations between individual CIMPs and specific somatic gene mutatio

• In the present study we

  2018-10-23

  

  In the present study, we have put considerable effort on carefully searching for published studies, setting strict criteria for study inclusion. There are some advantages that should be illustrated. Firstly, we have conducted a comprehensive search to identify more eligible studies thus, makes our a

• Planarians are a particularly well suited

  2018-10-23

  

  Planarians are a particularly well-suited animal model for the study of neoblast function, given the remarkable enrichment of this cell type in these animals (Reddien, 2013). Here, we showed that phagocyte depletion had no impact on instructed immunity. Instead, we found evidence of a critical role

• br Translating Senolytics into Clinical Treatments

  2018-10-23

  

  Translating Senolytics into Clinical Treatments Healthspan, lifespan, or other very long-term potential endpoints for clinical trials of interventions that target basic aging processes, including SASP-inhibitors or senolytics, would be difficult or next to impossible to study for reasons that are

• NAbs occurring after initial infection with HIV are generall

  2018-10-23

  

  NAbs occurring after initial infection with HIV-1 are generally not associated with any clinical or biological benefits. Doria-Rose et al. (2010) suggested that the limited breadth of neutralization observed in whole-serum samples from LTNP patients maybe attributable to low levels of antigenic stim

• br Acknowledgments We would like

  2018-10-23

  

  Acknowledgments We would like to thank Dr. Daniel Conrad and Julie Farnsworth at the Flow Cytometry Research Core at the Massey Cancer Center, VCU. This project was funded by the National Institute of Justice Award number 2013-DN-BX-K033. Data Experimental design, materials and methods A

• br Experimental design materials and

  2018-10-23

  

  Experimental design, materials and methods Acknowledgments This work was supported by Colon Cancer Canada and support for Dr. V. Ho (postdoctoral fellow) was provided by the Canadian Institutes of Health Research Postdoctoral Fellowship. Data These data were collected as described in detai

• br Funding This work was supported by Department of Health

  2018-10-23

  

  Funding This work was supported by Department of Health and Human Services Grants R01 FD003711 from the FDA Office of Orphan Products Development to Ney, P30-HD-03352, T32 DK007665 to Ney, and by the Clinical and Translational Science Award (CTSA) program, through the NIH National Center for Adva

15816 records 1052/1055 page Previous Next First page 上5页 10511052105310541055