It is known that synuclein is degraded in part

2018-10-20

It is known that α-synuclein is degraded in part by the autophagic/lysosomal pathway (Cuervo et al., 2004). We observed no differences for the intracellular α-synuclein levels in dopaminergic cultures derived from three patients carrying the GBA-N370S mutation, which is in line with the report of Sc

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank the members of the Department of Stem Cells and Developmental Biology for their discussions. We are grateful to Najmeh Sadat Masoudi for karyotyping, Fazel Samani for assistance with flow cytometry, and Mostafa Najar-Asl

br Results br Discussion In this

2018-10-20

Results Discussion In this study we have shown that activating BRAF mutations leading to increased RAS/MAPK pathway signaling induce a hypertrophic phenotype in hiPSC-derived CMs. While BRAF-mutant CMs display intrinsic defects in Ca2+ handling, several aspects of their phenotype require parac

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2018-07-29