br Experimental Procedures hESC derived

2018-10-20

Experimental Procedures hESC-derived RPE Tozadenant were manufactured in a fully validated good-manufacturing-practice (GMP) facility under strict environmental control monitoring systems and routine microbial testing regimens at CHA Biotech. Master and working cell banks were established using

br Author Contributions br Acknowledgments br Introduction N

2018-10-20

Author Contributions Acknowledgments Introduction Neurons in the CNS are particularly sensitive to injury and degenerative conditions that frequently result in cell death. Although adult neurogenesis persists in restricted troglitazone areas (Gage, 2000; Hsieh, 2012; Kriegstein and Alvarez

It has been reported that LPC like

2018-10-20

It has been reported that LPC-like coelenterazine were established from hESCs/hiPSCs (Takayama et al., 2013; Yanagida et al., 2013; Zhao et al., 2009), and these cells were shown to proliferate and differentiate into hepatocyte-like cells or cholangiocyte-like cells. These LPCs were either isolated

br Results br Discussion Following transplantation into

2018-10-20

Results Discussion Following transplantation into immunodeficient mice, immature hESC-derived pancreatic progenitor LJI308 develop over a lengthy maturation period into glucose-responsive, insulin secreting cells (Rezania et al., 2012; Bruin et al., 2013), although this process remains poorly

Another developmental regulator Hedgehog Hh acts as a morpho

2018-10-20

Another developmental regulator, Hedgehog (Hh), acts as a morphogen in many developing tissues. Visceral endoderm is instructive to the development of endothelial and hematopoietic cotransporter through Hh signaling early in mouse gastrulation (Belaoussoff et al., 1998; Dyer et al., 2001). Hh prote

It is known that synuclein is degraded in part

2018-10-20

It is known that α-synuclein is degraded in part by the autophagic/lysosomal pathway (Cuervo et al., 2004). We observed no differences for the intracellular α-synuclein levels in dopaminergic cultures derived from three patients carrying the GBA-N370S mutation, which is in line with the report of Sc

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank the members of the Department of Stem Cells and Developmental Biology for their discussions. We are grateful to Najmeh Sadat Masoudi for karyotyping, Fazel Samani for assistance with flow cytometry, and Mostafa Najar-Asl

br Results br Discussion In this

2018-10-20

Results Discussion In this study we have shown that activating BRAF mutations leading to increased RAS/MAPK pathway signaling induce a hypertrophic phenotype in hiPSC-derived CMs. While BRAF-mutant CMs display intrinsic defects in Ca2+ handling, several aspects of their phenotype require parac

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2018-07-29