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Para estimar la distribuci n de riqueza para los pa
2018-11-09
2) Para estimar la distribución de riqueza para los países sin datos, los autores hicieron uso de los datos de distribución del ingreso de 145 países registrados en el conjunto de datos wiid −otra vez, amable lector, se mezclaron dos variables por definición esencialmente distintas, el ingreso, un f
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Disclosure br Integration of biomarkers into the majority
2018-11-09
Disclosure Integration of biomarkers into the majority of drug development programs has led to a need for robust measurements and assay validation techniques for analyses of biological samples. The importance of solid methodologies for biomarker assessment is heightened by the fact that new drugs
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An important limitation of prior biomarkers studies
2018-11-09
An important limitation of prior biomarkers studies is that they included all stages of RCC (Takahashi et al., 2001; Sultmann et al., 2005; Kosari et al., 2005; Jones et al., 2005; Zhao et al., 2006; Cancer Genome Atlas Research N, 2013; Brannon et al., 2010), limiting their applicability to patient
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br Materials and methods br Results br Discussion
2018-11-08
Materials and methods Results Discussion Free radical damage can be considered as one of the major causative factors involved in many diseases such as inflammation and dementia. It is well established that anti-oxidants are capable of preventing injury to blood vessel membranes, thereby opt
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MRG was initially isolated as a member of gene family
2018-11-08
MRG15 was initially isolated as a member of gene family that is related to cellular senescence and cell growth control and is evolutionarily highly conserved (). MRG15 has a chromodomain in the N-terminus () and can directly bind to di- or tri-methylated histone H3 at lysine 36 (H3K36me) through thi
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Subsets of undifferentiated human ES cells have been propose
2018-11-08
Subsets of undifferentiated human ES cells have been proposed based upon studies of surface antigen markers, such as SSEA3 (Enver et al., 2005) or CD9 and GCTM2 (Laslett et al., 2007). SSEA3 is a cell surface antigen that is rapidly down-regulated as human ES cells differentiate (Draper et al., 200
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br Results br Discussion We have demonstrated that
2018-11-08
Results Discussion We have demonstrated that the hPSC-derived HBCs could be maintained on a human LN111-coated dish in an integrin α6- and β1-dependent manner (Figure 1). It is known that undifferentiated hPSCs could be maintained on a human LN511-coated dish but not on a human LN111-coated di
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While the in vivo significance of
2018-11-08
While the in vivo significance of our in vitro findings was examined in xenograft and metastasis studies, we observed a dramatic suppression of tumor growth and metastasis of SW480 CRC hsp90 inhibitors by EDA silencing, which is associated with increased apoptosis and reduced expression of a cell p
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br Materials and methods br Results br Discussion We
2018-11-08
Materials and methods Results Discussion We have demonstrated the efficient generation of high numbers of bfCNs from hPSCs via an expandable basal forebrain NSC intermediate. This is of particular interest as bfCNs are one of the primary populations affected in AD, and our protocol provides
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br The important role of the Hippo
2018-11-08
The important role of the Hippo kinase cascade in suppressing cell proliferation led Heallen, Martin, and colleagues to hypothesize that Hippo signaling deficiency would cause cardiac overgrowth. This hypothesis was supported by the cardiac-restricted inactivation of Mst1/2, Sav1, and Lats2, which
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synthase In demyelinating diseases injury of myelin
2018-11-08
In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as
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Our experiments suggest that Runx may be a useful
2018-11-08
Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic ras pathway injury. Runx1 over-expression has been demonstrated to facilitate neuronal differentiation and long-range
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Neurospheres are also a good source of neural progenitors fo
2018-11-08
Neurospheres are also a good source of neural progenitors for neural transplantation due to their easy delivery and ability to migrate (Matigian et al., 2010; Englund et al., 2002; Flax et al., 1998; Betarbet et al., 1996). However, clumping has been a challenge for neurodifferentiation both in vivo
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In our previous studies we successfully synthesized poly
2018-11-08
In our previous studies, we successfully synthesized poly(hydroxyethyl methacrylate) (pHEMA) derived-polymers differing in the amount of 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) (Rosso et al., 2003; De Rosa et al., 2004). We demonstrated that positively charged moieties on the polym
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We focused on a member of the
2018-11-08
We focused on a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) protein class, LGR5 (McDonald et al., 1998). LGR5 functions within the Wingless-related integration site (WNT) signaling cascade, which maintains the adult intestinal stem cell compartment (de Lau et al., 2
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